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The efficiency of adjusted-da-chai-ling-tang in radiation-induced brain edema in patients with brain tumors
Da-Tong Ju1, Hsing-Lung Chao2, Chen-Yu Lee3, Shin-Fang Chung4, Cheng-Ta Hsieh5
1 Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
2 Department of Radiaiton Onoclogy, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
3 Yu-Sheng Chinese Medical Clinic, Cathay General Hospital, Taipei, Taiwan
4 Sappho's Clinic, Cathay General Hospital, Taipei, Taiwan
5 Department of Surgery, Division of Neurosurgery, Cathay General Hospital, Taipei; Department of Medicine, School of Medicine, Fu Jen Catholic University, New Taipei City; Graduate Institute of Basic Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
Correspondence Address:
Cheng-Ta Hsieh
Department of Surgery, Division of Neurosurgery, Cathay General Hospital, 280, Section 4, Jen-Ai Road, Taipei 106
Taiwan
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/1011-4564.151285
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Background: Brain edema induced by radiotherapy is a common complication in patients with brain tumors, for which medical treatment is the treatment of choice. Adjusted-Da-Chai-Ling-Tang, a Chinese herbal formulation, has been confirmed to be protective against the radiation-induced edema. In this study, we investigated the efficiency of adjusted-Da-Chai-Ling-Tang in radiation-induced brain edema in patients with brain tumors. Materials and Methods: A total of 46 patients with brain tumors treated with radiotherapy alone or combined with surgery were enrolled. These patients were divided into two groups: The experimental group with adjusted-Da-Chai-Ling-Tang and the control group with conventional medical treatment. Clinical data including symptoms and serologic results were collected pretreatment and on the 4 th , 7 th and 10 th day posttreatment. Magnetic resonance imaging of the brain was performed to investigate changes in brain edema. Results: Clinical symptoms including headache, dizziness, nausea/vomiting and fatigue significantly improved in the experimental group (P < 0.05). No difference in serological results was observed. Brain edema was significantly reduced in the experimental group in magnetic resonance imaging (P < 0.05). Conclusion: Adjusted-Da-Chai-Ling-Tang is effective in the treatment of radiation-induced brain edema in patients with brain tumors. No obvious side effects were observed.
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