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Cutaneous adverse drug reactions in a tertiary hospital in Taipei, Taiwan, in 2018
Yi-Hsien Chen1, Tzu-Ling Hung2, Hsiang-Cheng Chen3, Jui-Hu Shih4, Yu-Ju Chiao5, Li-Ching Lin5, Chih-Tsung Hung6
1 Department of Dermatology, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
2 Department of Dermatology, National Defense Medical Center, Tri-Service General Hospital, Taipei; Department of Dermatology, Armed-Forces Taoyuan General Hospital, Taoyuan, Taiwan
3 Department of Internal Medicine, Division of Rheumatology/Immunology/Allergy, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
4 Department of Pharmacy Practice, Tri-Service General Hospital; National Defense Medical Center, School of Pharmacy, Taipei, Taiwan
5 Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan
6 Department of Dermatology, National Defense Medical Center, Tri-Service General Hospital; National Defense Medical Center, Graduate Institute of Medical Sciences, Taipei, Taiwan
Correspondence Address:
Dr. Chih-Tsung Hung
Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Road, Neihu Dist., Taipei City 114
Taiwan
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: :10.4103/jmedsci.jmedsci_172_19
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Cutaneous adverse drug reactions (CADRs) are the common adverse reactions ranging from mild self-limiting skin rash to the life-threatening severe cutaneous adverse reactions. Aims: The aim of the study was to describe the demographic characteristics of patients, different clinical patterns, and implicated drugs. Methods: This was a retrospective study by analyzing the database established for all ADRs reported from January 1, 2018, to December 31, 2018, in a tertiary care teaching hospital in Taipei, Taiwan. Results: A total of 126 cases of CADRs were reported in 2018. The mean age of patients was 59.06 ± 21.63 years, with a peaking at 60–79-year-old (31.7%) and followed by 40–59-year-old (25.4%). The male-to-female ratio was 1.03:1. The most common skin reaction pattern was maculopapular eruptions (59.5%), followed by angioedema (11.9%), phlebitis (6.3%), and urticaria (6.3%). Most of the CADRs were reported with antibacterials (66.7%), followed by anti-inflammatory products (11.9%), contrast media (4.8%), and antithrombotic agents (3.2%). Conclusions: We listed the patient characteristics, each pattern of CADRs, and their associated drugs. Such information could help health-care professionals to assess CADRs and evaluate suspected drugs timely and accurately.
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