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Vaginal delivery with immune thrombocytopenic purpura-induced severe thrombocytopenia

1 Department of Obstetrics and Gynecology, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan
2 Department of Medicine, Division of Hematology and Oncology, Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan

Correspondence Address:
Kuo-Min Su,
Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmedsci.jmedsci_417_20

Idiopathic thrombocytopenic purpura (ITP) is the most common immune-related thrombocytopenia during pregnancy. Here, we present a case of ITP with acute flare-up during pregnancy. Worsening thrombocytopenia dropped the platelet count to 11,000/dL. Steroid treatment, intravenous immunoglobulin (IVIG) infusion, and anti-CD20 antibody therapy were all unsuccessful. Fortunately, no further critical maternal or fetal complications developed. Transient neonatal thrombocytosis was noted after delivery but was corrected with IVIG.


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