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CASE REPORT

A Case of refractory t-cell lymphoblastic lymphoma coexisting with zmym2-fibroblastic growth factor receptor-1 fusion-related myeloproliferative disease and review of literatures


 Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Correspondence Address:
Yi-Ying Wu,
Division of Hematology and Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sector 2, Neihu 114, Taipei
Taiwan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmedsci.jmedsci_230_21

T-cell LBL (T-LBL) is a rare lymphoma subtype in adults, and it usually has a dismal prognosis compared to other subtypes of non-Hodgkin lymphoma. Here, we present a unique case of T-LBL with myeloproliferative disease. A distinct fusion gene of ZMYM2-FGFR1 translocation was detected through next-generation sequencing, and this might be correlated with the translocation of chromosomes 8 and 13 (t[8;13]). Her disease condition seemed to be refractory to multiple lines of chemotherapy. Her lymphoma finally achieved a complete remission after a matched related allogeneic hematopoietic stem cell transplantation.


 

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    -  Yu TY
    -  Huang TC
    -  Wu YY
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