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Potential utility of tranexamic acid in combat trauma


 Department of Anaesthesiology and Critical Care, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Shalendra Singh,
Department of Anaesthesiology and Critical Care, Armed Forces Medical College, Pune - 411 040, Maharashtra
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmedsci.jmedsci_266_21

Tranexamic acid (TXA) lessens surgical bleeding and reduces mortality in patients with traumatic hemorrhage. Hemorrhage is common in combat zones and is one of the most common causes of mortality in a war scenario. The management of hemorrhage involves early arrest/temporization of ongoing bleed and restoration of blood volume to restore physiological stability as soon as possible. TXA by its antifibrinolytic action decreases blood loss, thus circumventing the requirement of massive crystalloid resuscitation, in turn an important causative factor for acute traumatic coagulopathy. Currently, TXA is recommended in acute hemorrhage worldwide; thus, its use in the combat scenario needs to be conceptualized by the primary caregivers. This conceptualization will be discussed in detail in this review article.


 

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