Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 41  |  Issue : 6  |  Page : 286--294

Epidemiology profile and outcomes of oral potentially malignant disorders among different geographic regions of Taiwan: A retrospective observational nationwide population database study


Sheng-Fu Chiu1, Chung-Han Ho2, Yi-Chen Chen3, Li-Wha Wu4, Yuh-Ling Chen5, Jer-Horng Wu6, Wei-Sheng Wu7, Hui-Kun Hung8, Wei-Fan Chiang9 
1 Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Liouying, Taiwan
2 Department of Medical Research, Chi Mei Medical Center; Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan, Taiwan
3 Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
4 Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan; Department of Laboratory Science and Technology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
5 Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
6 Department of Environmental Engineering, National Cheng Kung University, Tainan, Taiwan
7 Department of Electrical Engineering, National Cheng Kung University, Tainan, Taiwan
8 Department of Plastic Surgery, Chi Mei Medical Center, Liouying, Taiwan
9 Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Liouying; Department of School of Dentistry, National Yang Ming University, Taipei, Taiwan

Correspondence Address:
Dr. Wei-Fan Chiang
No. 201 Taikang, Liouying, Tainan 73657
Taiwan

Background: The malignant transformation of oral potentially malignant disorders (OPMDs) is a potential cause of oral cancers. However, epidemiological studies on malignant transformation of OPMDs are lacking. The present study is aimed to investigate the percentage of OPMD in the oral mucosal screening database and the malignant transformation (%) across different regions of Taiwan. Methods: We determined the cases of malignant transformation of OPMD to oral cancers during the 2-year follow-up by the oral mucosal screening database and the cancer registry database contained in the National Health Insurance Research Database. Patients with oral cancer history before OPMD diagnosis were excluded from the study. We collected data including clinical diagnosis, biopsy result, follow-up, and place of residence of the patient. The most widely used definition from the Council for Economic Planning and Development in Taiwan was used in this study for the classification into Southern, Northern, Eastern, and Western Taiwan regions. Differences in the malignant transformation (%) and ranking between regions were evaluated using analysis of variance test. Results: Chiayi city located in Southern Taiwan has the highest percentage of OPMD in oral screening citizen. The percentage of OPMD in the oral mucosal screening database was highest in Southern Taiwan and lowest in Eastern Taiwan; however, the malignant transformation (%) was highest in the Eastern Taiwan and lowest in Northern Taiwan. Conclusion: Dentists and otolaryngologists in Southern Taiwan, especially Chiayi city, should be cautious when screening the patient because of the high percentage of OPMD in oral mucosal screening database. The percentage of OPMD in the oral mucosal screening database and the malignant transformation (%) are different among the different regions in Taiwan. Further research is needed to clarify the reasons for the different malignant transformation (%) between regions.


How to cite this article:
Chiu SF, Ho CH, Chen YC, Wu LW, Chen YL, Wu JH, Wu WS, Hung HK, Chiang WF. Epidemiology profile and outcomes of oral potentially malignant disorders among different geographic regions of Taiwan: A retrospective observational nationwide population database study.J Med Sci 2021;41:286-294


How to cite this URL:
Chiu SF, Ho CH, Chen YC, Wu LW, Chen YL, Wu JH, Wu WS, Hung HK, Chiang WF. Epidemiology profile and outcomes of oral potentially malignant disorders among different geographic regions of Taiwan: A retrospective observational nationwide population database study. J Med Sci [serial online] 2021 [cited 2021 Nov 27 ];41:286-294
Available from: https://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2021;volume=41;issue=6;spage=286;epage=294;aulast=Chiu;type=0